Epsilon toxin from Clostridium perfringens acts on oligodendrocytes without forming pores, and causes demyelination.

@article{Wioland2015EpsilonTF,
  title={Epsilon toxin from Clostridium perfringens acts on oligodendrocytes without forming pores, and causes demyelination.},
  author={Laetitia Wioland and Jean-Luc Dupont and Fr{\'e}d{\'e}ric Doussau and St{\'e}phane Gaillard and Flavia Heid and Philippe Isope and Serge Pauillac and Michel Robert Popoff and J. L. Bossu and Bernard Poulain},
  journal={Cellular microbiology},
  year={2015},
  volume={17 3},
  pages={369-88}
}
Epsilon toxin (ET) is produced by Clostridium perfringens types B and D and causes severe neurological disorders in animals. ET has been observed binding to white matter, suggesting that it may target oligodendrocytes. In primary cultures containing oligodendrocytes and astrocytes, we found that ET (10(-9) M and 10(-7) M) binds to oligodendrocytes, but not to astrocytes. ET induces an increase in extracellular glutamate, and produces oscillations of intracellular Ca(2+) concentration in… CONTINUE READING