Epsilon-isoenzyme of protein kinase C induces a Ca(2+)-independent contraction in vascular smooth muscle.

@article{Horowitz1996EpsilonisoenzymeOP,
  title={Epsilon-isoenzyme of protein kinase C induces a Ca(2+)-independent contraction in vascular smooth muscle.},
  author={Arie Horowitz and Odile Cl{\'e}ment-Chomienne and M. P. Walsh and Kathleen G Morgan},
  journal={The American journal of physiology},
  year={1996},
  volume={271 2 Pt 1},
  pages={C589-94}
}
We provide here the first direct evidence for in situ functional specificity of protein kinase C (PKC)-epsilon as a regulator of smooth muscle contractility. PKC is known to cause a Ca(2+)-independent contraction of ferret aortic smooth muscle, and the expression of two Ca(2+)-independent PKC isoenzymes, epsilon and zeta, has been demonstrated in this tissue. To test directly the hypothesis that one of these isoenzymes regulates contractility, constitutively active forms of PKC-epsilon and PKC… CONTINUE READING
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