Eps8 in the midst of GTPases.

  title={Eps8 in the midst of GTPases.},
  author={Pier Paolo Di Fiore and Giorgio Scita},
  journal={The international journal of biochemistry & cell biology},
  volume={34 10},
Eps8, originally identified as a substrate for the kinase activity of the epidermal growth factor receptor (EGFR), displays a domain organization typical of a signaling molecule that includes a putative N-terminal PTB domain, a central SH3 domain, and a C-terminal "effector region". This latter region directs Eps8 localization within the cell and is sufficient to activate the GTPase, Rac, leading to actin cytoskeletal remodeling. Eps8 binds, through its SH3 domain, to either Abi1 (also called… CONTINUE READING
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