Epratuzumab for patients with moderate to severe flaring SLE: health-related quality of life outcomes and corticosteroid use in the randomized controlled ALLEVIATE trials and extension study SL0006

@inproceedings{Strand2014EpratuzumabFP,
  title={Epratuzumab for patients with moderate to severe flaring SLE: health-related quality of life outcomes and corticosteroid use in the randomized controlled ALLEVIATE trials and extension study SL0006},
  author={Vibeke Strand and Michelle Petri and Kenneth Carekin Kalunian and Caroline P. Gordon and Daniel Wallace and Kathryn Virginia Hobbs and Lexy Kelley and Brian Kilgallen and William A. Wegener and David M. Goldenberg},
  booktitle={Rheumatology},
  year={2014}
}
OBJECTIVE To evaluate health-related quality of life (HRQOL) and corticosteroid use in patients with moderate to severely active SLE enrolled in two international, multicentre, randomized controlled trials of epratuzumab (ALLEVIATE-1 and -2) and a long-term extension study (SL0006). METHODS Ninety ALLEVIATE patients (43% BILAG A, mean BILAG score 13.2) were randomized to receive 360 mg/m(2) (n = 42) or 720 mg/m(2) (n = 11) epratuzumab or placebo (n = 37), plus standard of care, in 12-week… CONTINUE READING

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