Epoxygenase metabolites of docosahexaenoic and eicosapentaenoic acids inhibit platelet aggregation at concentrations below those affecting thromboxane synthesis.

  • M Vanrollins
  • Published 1995 in
    The Journal of pharmacology and experimental…


Docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids are the major n-3 fatty acids in fish oils. When either DHA or EPA is added to platelet suspensions, aggregation and thromboxane synthesis are both suppressed. However, when DHA or EPA is provided as a dietary supplement, only platelet aggregation is impaired during the early phase of the diet. In the… (More)


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