Epoxyeicosatrienoic acids prevent cisplatin-induced renal apoptosis through a p38 mitogen-activated protein kinase-regulated mitochondrial pathway.

@article{Liu2013EpoxyeicosatrienoicAP,
  title={Epoxyeicosatrienoic acids prevent cisplatin-induced renal apoptosis through a p38 mitogen-activated protein kinase-regulated mitochondrial pathway.},
  author={Yingmei Liu and Xiaodan Lu and Sinh Hoa Nguyen and Jean L. Olson and Heather Kay Webb and Deanna L. Kroetz},
  journal={Molecular pharmacology},
  year={2013},
  volume={84 6},
  pages={925-34}
}
Soluble epoxide hydrolase (sEH) catalyzes the conversion of epoxyeicosatrienoic acids into less active eicosanoids, and inhibitors of sEH have anti-inflammatory and antiapoptotic properties. Based on previous observations that sEH inhibition attenuates cisplatin-induced nephrotoxicity by modulating nuclear factor-κB signaling, we hypothesized that this strategy would also attenuate cisplatin-induced renal apoptosis. Inhibition of sEH with AR9273 [1-adamantan-1-yl-3-(1-methylsulfonyl-piperidin-4… CONTINUE READING

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