Epoxyeicosatrienoic acids enhance axonal growth in primary sensory and cortical neuronal cell cultures.

@article{Abdu2011EpoxyeicosatrienoicAE,
  title={Epoxyeicosatrienoic acids enhance axonal growth in primary sensory and cortical neuronal cell cultures.},
  author={Emun Abdu and Donald A Bruun and Dongren Yang and Jun Yang and Bora Inceoğlu and Bruce D Hammock and Nabil J. Alkayed and Pamela J Lein},
  journal={Journal of neurochemistry},
  year={2011},
  volume={117 4},
  pages={
          632-42
        }
}
It has recently been reported that soluble epoxide hydrolase (sEH), the major enzyme that metabolizes epoxyeicosatrienoic acids (EETs), is expressed in axons of cortical neurons; however, the functional relevance of axonal sEH localization is unknown. Immunocytochemical analyses demonstrate predominant axonal localization of sEH in primary cultures of not only cortical but also sympathetic and sensory neurons. Morphometric analyses of cultured sensory neurons indicate that exposure to a… CONTINUE READING

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