Epoxyeicosatrienoic acid analogue lowers blood pressure through vasodilation and sodium channel inhibition.

@article{Khan2014EpoxyeicosatrienoicAA,
  title={Epoxyeicosatrienoic acid analogue lowers blood pressure through vasodilation and sodium channel inhibition.},
  author={Md Abdul Hye Khan and Tengis S Pavlov and Sarah V Christain and Jan Neck{\'a}ř and Alexander Staruschenko and Kathryn M. Gauthier and J. Capdevila and John R Falck and William Campbell and John D. Imig},
  journal={Clinical science},
  year={2014},
  volume={127 7},
  pages={463-74}
}
Epoxyeicosatrienoic acids (EETs) contribute to haemodynamics, electrolyte homoeostasis and blood pressure regulation, leading to the concept that EETs can be therapeutically targeted for hypertension. In the present study, multiple structural EET analogues were synthesized based on the EET pharmacophore and vasodilator structure-activity studies. Four EET analogues with 91-119% vasodilatory activity in the isolated bovine coronary artery (EC50: 0.18-1.6 μM) were identified and studied for blood… CONTINUE READING

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