Epoxy-silane linking of biomolecules is simple and effective for patterning neuronal cultures.

  title={Epoxy-silane linking of biomolecules is simple and effective for patterning neuronal cultures.},
  author={Yoonkey Nam and Darren W. Branch and Bruce C. Wheeler},
  journal={Biosensors & bioelectronics},
  volume={22 5},
Surface chemistry is one of the main factors that contributes to the longevity and compliance of cell patterning. Two to three weeks are required for dissociated, embryonic rat neuronal cultures to mature to the point that they regularly produce spontaneous and evoked responses. Though proper surface chemistry can be achieved through the use of covalent protein attachment, often it is not maintainable for the time periods necessary to study neuronal growth. Here we report a new and effective… CONTINUE READING
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