Epoxide metabolizing enzyme activities in rat testes: postnatal development and relative activity in interstitial and spermatogenic cell compartments.

@article{Mukhtar1978EpoxideME,
  title={Epoxide metabolizing enzyme activities in rat testes: postnatal development and relative activity in interstitial and spermatogenic cell compartments.},
  author={Hasan Mukhtar and I. P. Lee and Gary L Foureman and John Richard Bend},
  journal={Chemico-biological interactions},
  year={1978},
  volume={22 2-3},
  pages={153-65}
}
Microsomal epoxide hydrase (EH) and 176 000 g supernatant fraction glutathione-S-transferase (GSH-S-T) activities were determined with styrene oxide as substrate in rat testes during postnatal development. The development of these enzymes was also followed in liver for comparison. Testes of 6-day-old rats had high GSH-S-T activities (66 nmol/min/mg protein), which were about 50% of the adult levels. Transferase activity then developed slowly and reached a maximum by 165 days of age. Specific… CONTINUE READING