Epoxide formation from diallyl sulfone is associated with CYP2E1 inactivation in murine and human lungs.

@article{Forkert2000EpoxideFF,
  title={Epoxide formation from diallyl sulfone is associated with CYP2E1 inactivation in murine and human lungs.},
  author={P. G. Forkert and Peter D. Premdas and Raymond J. Bowers},
  journal={American journal of respiratory cell and molecular biology},
  year={2000},
  volume={23 5},
  pages={
          687-95
        }
}
We tested the hypothesis that an epoxide formed from diallyl sulfone (DASO(2)) is responsible for inactivation of CYP2E1 in murine and human lungs. An epoxide (1,2-epoxypropyl-3,3'-sulfonyl-1'-propene [DASO(3)]) was synthesized from DASO(2) and conjugated with glutathione (GSH) to produce the conjugates S-(1R, S-[[1-hydroxymethyl-2,3' -sulfonyl]-1' -propenyl]ethyl)glutathione (diastereomers) and S-(1-[[2R,S-hydroxypropyl]-3, 3'-sulfonyl]-1'-propenyl)glutathione (diastereomers). Analysis of… CONTINUE READING

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