Epothilone B stabilizes microtubuli of macrophages like taxol without showing taxol-like endotoxin activity.

@article{Muhlradt1997EpothiloneBS,
  title={Epothilone B stabilizes microtubuli of macrophages like taxol without showing taxol-like endotoxin activity.},
  author={Peter F. Muhlradt and Florenz Sasse},
  journal={Cancer research},
  year={1997},
  volume={57 16},
  pages={3344-6}
}
Epothilones are a new class of potential antitumor compounds that were isolated from the myxobacterium Sorangium cellulosum. Epothilones have effects on the cytoskeleton similar to those of the antineoplastic drug Taxol. Both compounds inhibit cell proliferation by stabilizing microtubuli, and they compete for the same binding site. In addition, Taxol… CONTINUE READING