Eplerenone inhibits aldosterone-induced CRP generation in rat vascular smooth muscle cells by regulating the MR-ROS-ERK1/2 signal pathway

@article{Zhang2017EplerenoneIA,
  title={Eplerenone inhibits aldosterone-induced CRP generation in rat vascular smooth muscle cells by regulating the MR-ROS-ERK1/2 signal pathway},
  author={Xiaolu Zhang and Juntian Liu and Xiaoming Pang and Jingjing Zhao and Shouzhu Xu and Jing Zhao},
  journal={European Journal of Inflammation},
  year={2017},
  volume={15},
  pages={210 - 218}
}
Atherosclerosis is a chronic inflammatory disease in the vessel wall. As a representative inflammatory cytokine, C-reactive protein (CRP) participates in the formation and development of atherosclerosis. It is demonstrated that aldosterone induces CRP generation in vascular smooth muscle cells (VSMCs). This study explored the inhibitory effect of eplerenone on aldosterone-induced CRP expression in VSMCs and mechanism. In the in vitro experiments, rat VSMCs were cultured and aldosterone (10 nM… CONTINUE READING