Eplerenone in patients with systolic heart failure and mild symptoms.

@article{Zannad2011EplerenoneIP,
  title={Eplerenone in patients with systolic heart failure and mild symptoms.},
  author={F. Zannad and J. McMurray and H. Krum and D. V. van Veldhuisen and K. Swedberg and Harry Shi and J. Vincent and S. Pocock and B. Pitt},
  journal={The New England journal of medicine},
  year={2011},
  volume={364 1},
  pages={
          11-21
        }
}
BACKGROUND Mineralocorticoid antagonists improve survival among patients with chronic, severe systolic heart failure and heart failure after myocardial infarction. We evaluated the effects of eplerenone in patients with chronic systolic heart failure and mild symptoms. METHODS In this randomized, double-blind trial, we randomly assigned 2737 patients with New York Heart Association class II heart failure and an ejection fraction of no more than 35% to receive eplerenone (up to 50 mg daily) or… Expand
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References

SHOWING 1-10 OF 30 REFERENCES
The clinical implications of aldosterone escape in congestive heart failure
  • 106
...
1
2
3
...