Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction.

  title={Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction.},
  author={Bertram C Pitt and Willem F. Remme and Fa{\"i}ez Zannad and James Neaton and Felipe Mart{\'i}nez and Barbara Roniker and Richard M. Bittman and Steve Hurley and Jay H Kleiman and Marjorie R Gatlin},
  journal={The New England journal of medicine},
  volume={348 14},
BACKGROUND Aldosterone blockade reduces mortality and morbidity among patients with severe heart failure. We conducted a double-blind, placebo-controlled study evaluating the effect of eplerenone, a selective aldosterone blocker, on morbidity and mortality among patients with acute myocardial infarction complicated by left ventricular dysfunction and heart failure. METHODS Patients were randomly assigned to eplerenone (25 mg per day initially, titrated to a maximum of 50 mg per day; 3319… CONTINUE READING
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Aldosterone induces a vascular inflammatory phenotype in the rat heart.

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Effects of long - term monotherapy with eplerenone , a novel aldosterone blocker , on progression of left ventricular dysfunction and remodeling in dogs with heart failure

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