Epitopes required for antibody-dependent enhancement of Ebola virus infection.

  title={Epitopes required for antibody-dependent enhancement of Ebola virus infection.},
  author={Ayato Takada and Hideki Ebihara and Heinz Feldmann and Thomas W. Geisbert and Yoshihiro Kawaoka},
  journal={The Journal of infectious diseases},
  volume={196 Suppl 2},
We have shown that antibody-dependent enhancement (ADE) of infection with Zaire Ebola virus (ZEBOV) is mediated by interaction of virus-specific antibodies with Fc receptors or complement component C1q and its receptors in vitro. ADE activities of the antisera to the viral glycoprotein (GP) were virus species specific and were primarily correlated with immunoglobulin (Ig) G2a and IgM levels but not with IgG1 levels. Interestingly, compared with ZEBOV, Reston Ebola virus (REBOV) had… CONTINUE READING


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