Epitope-specific induction of mesangial lesions with proteinuria by a MoAb against mesangial cell surface antigen.

@article{Kawachi1992EpitopespecificIO,
  title={Epitope-specific induction of mesangial lesions with proteinuria by a MoAb against mesangial cell surface antigen.},
  author={Hiroshi Kawachi and Michiaki Orikasa and Katsuyuki Matsui and Toshihiko Iwanaga and Shinichi Toyabe and Takashi Oite and Fujio Shimizu},
  journal={Clinical and experimental immunology},
  year={1992},
  volume={88 3},
  pages={399-404}
}
A MoAb 1-22-3 (IgG3) was produced in mice immunized with rat glomeruli. A blotting study indicated the antigen molecule recognized by this MoAb has a molecular weight of about 25 kD, which is the same as that of the Thy 1.1 molecule. This MoAb is capable of inducing the morphological changes similar to those induced by anti-thymocyte serum or the anti-Thy 1.1 MoAb, ER4 and massive proteinuria in rats by a single i.v. injection. Proteinuria started immediately after MoAb 1-22-3 injection and… CONTINUE READING