Epitope-specific antibody-induced cleavage of angiotensin-converting enzyme from the cell surface.

@article{Balyasnikova2002EpitopespecificAC,
  title={Epitope-specific antibody-induced cleavage of angiotensin-converting enzyme from the cell surface.},
  author={Irina V. Balyasnikova and Eric H. Karran and Ii Ronald F. Albrecht and Sergei M Danilov},
  journal={The Biochemical journal},
  year={2002},
  volume={362 Pt 3},
  pages={
          585-95
        }
}
Angiotensin I-converting enzyme (ACE; CD143, EC 3.4.15.1) is a type-1 integral membrane protein that can also be released into extracellular fluids (such as plasma, and seminal and cerebrospinal fluids) as a soluble enzyme following cleavage mediated by an unidentified protease(s), referred to as ACE secretase, in a process known as "shedding". The effects of monoclonal antibodies (mAbs) to eight different epitopes on the N-terminal domain of ACE on shedding was investigated using Chinese… CONTINUE READING

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