Epitope regions in the heavy chain of Clostridium botulinum type E neurotoxin recognized by monoclonal antibodies.

@article{Kubota1997EpitopeRI,
  title={Epitope regions in the heavy chain of Clostridium botulinum type E neurotoxin recognized by monoclonal antibodies.},
  author={Toshiya Kubota and Takashi Watanabe and Noriko Yokosawa and Keisuke Tsuzuki and Tomokazu Indoh and Kohji Moriishi and Komla Sanda and Yonosuke Maki and Katsuhisa Inoue and Nobuhiro Fujii},
  journal={Applied and environmental microbiology},
  year={1997},
  volume={63 4},
  pages={1214-8}
}
Seventeen monoclonal antibodies (MAbs) were previously established against the heavy chain (Hc) of botulinum type E neurotoxin in BALB/c mice immunized with the type E toxoid. Five MAbs (LE15-5, LE34-6, EK19-7, EK21-4, and AE27-9) showed toxin-neutralizing activity in mice. Two of the five MAbs, EK19-7 and EK21-4, recognized the regions located at amino acid positions 731 to 787 and 811 to 897, respectively. One of the remaining three antibodies (LE34-6) reacted with the amino acid sequence… CONTINUE READING

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