Epitope mapping of monoclonal antibodies against Bordetella pertussis adenylate cyclase toxin.

@article{Lee1999EpitopeMO,
  title={Epitope mapping of monoclonal antibodies against Bordetella pertussis adenylate cyclase toxin.},
  author={Susan J. Lee and Mary C. Gray and L. -H. Guo and Peter {\vS}ebo and Erik L. Hewlett},
  journal={Infection and immunity},
  year={1999},
  volume={67 5},
  pages={
          2090-5
        }
}
Adenylate cyclase (AC) toxin from Bordetella pertussis is a 177-kDa repeats-in-toxin (RTX) family protein that consists of four principal domains; the catalytic domain, the hydrophobic domain, the glycine/aspartate-rich repeat domain, and the secretion signal domain. Epitope mapping of 12 monoclonal antibodies (MAbs) directed against AC toxin was conducted to identify regions important for the functional activities of this toxin. A previously developed panel of in-frame deletion mutants of AC… CONTINUE READING

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Oligomerization is involved in pore formation by Bordetella adenylate cyclase toxin.

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2009
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