Epitope mapping of a series of human thymidylate synthase monoclonal antibodies.

@article{Behan1998EpitopeMO,
  title={Epitope mapping of a series of human thymidylate synthase monoclonal antibodies.},
  author={K A Behan and Peter G. Johnston and Carmen Joseph Allegra},
  journal={Cancer research},
  year={1998},
  volume={58 12},
  pages={2606-11}
}
We have reported previously the development and application of several monoclonal antibodies to thymidylate synthase (TS). In this study, we used a series of overlapping 17-mer peptides that spanned the entire TS protein to map the epitope recognized by three TS monoclonal antibodies (TS 106, TS 109, and TS 110). Using an ELISA, we identified two peptides (R126-F142 and L131-R147) that bound all three antibodies, which suggests that each antibody recognized a similar epitope on TS. A second set… CONTINUE READING

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