Epitope map for a growth hormone receptor agonist monoclonal antibody, MAb 263.

@article{Wan2003EpitopeMF,
  title={Epitope map for a growth hormone receptor agonist monoclonal antibody, MAb 263.},
  author={Yu Hui Wan and Yuan Zhi Zheng and Jonathan McKinley Harris and Richard R. Brown and Michael J. Waters},
  journal={Molecular endocrinology},
  year={2003},
  volume={17 11},
  pages={2240-50}
}
Monoclonal antibody (MAb) 263 is a widely used monoclonal antibody that recognizes the extracellular domain (ECD) of the GH receptor. It has been shown to act as a GH agonist both in vitro and in vivo, and we report here that it must be divalent to exert its effect on the full-length receptor. To understand the mechanism of its agonist action, we have determined the precise epitope for this antibody using a novel random PCR mutagenesis approach together with expression screening in yeast. A… CONTINUE READING

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