Epitope-dependent localization of estrogen receptor-alpha, but not -beta, in en face arterial endothelium.

@article{Dan2003EpitopedependentLO,
  title={Epitope-dependent localization of estrogen receptor-alpha, but not -beta, in en face arterial endothelium.},
  author={P. Ho{\'a}ng The Dan and Joyce C.Y. Cheung and David R. L. Scriven and Edwin D. W. Moore},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2003},
  volume={284 4},
  pages={
          H1295-306
        }
}
Rapid, nongenomic effects of 17 beta-estradiol (E(2)) in endothelial cells are postulated to arise from membrane-associated estrogen receptors (ERs), which have not been visualized in vascular tissue. To identify membrane ERs, we used multiple site-directed ER alpha or ER beta antibodies to label en face rat cerebral and coronary arterial endothelia. Western blots revealed a novel 55-kDa ER alpha isoform. Three-dimensional images of cells labeled with these antibodies and markers for the… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 26 CITATIONS

Similar Papers

Loading similar papers…