Epitope-defined monoclonal antibodies against type-IV collagen for diagnosis of Alport's syndrome.

@article{Kagawa1997EpitopedefinedMA,
  title={Epitope-defined monoclonal antibodies against type-IV collagen for diagnosis of Alport's syndrome.},
  author={Megumi Kagawa and Yumiko Kishiro and Ichiro Naito and Takahiro Nemoto and Hiroyuki Nakanishi and Yoshifumi Ninomiya and Yoshikazu Sado},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={1997},
  volume={12 6},
  pages={1238-41}
}
BACKGROUND Alport's syndrome can be diagnosed by staining the alpha 5 chain of type IV collagen in kidney biopsy specimens with a monoclonal antibody. Because antibodies already established against the alpha 5 chain require denaturation treatment of cryostat sections to expose their epitopes. To save time and effort for staining, a new epitope-defined… CONTINUE READING