Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology.

@article{Bard2003EpitopeAI,
  title={Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology.},
  author={Fr{\'e}d{\'e}rique Bard and Robin M. Barbour and Catherine Cannon and Robert Carretto and Michael D. Fox and Dora Games and Teresa Guido and Kathleen Hoenow and Kang Hu and Kelly Johnson-wood and Karen A. Khan and Dora Kholodenko and Celeste Lee and Mike X Lee and Ruth Motter and Minh Anh H Nguyen and Amanda Reed and Dale Schenk and Pearl Mao Tang and Nicki Vasquez and Peter Seubert and Ted A. Yednock},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 4},
  pages={2023-8}
}
Transgenic PDAPP mice, which express a disease-linked isoform of the human amyloid precursor protein, exhibit CNS pathology that is similar to Alzheimer's disease. In an age-dependent fashion, the mice develop plaques containing beta-amyloid peptide (Abeta) and exhibit neuronal dystrophy and synaptic loss. It has been shown in previous studies that pathology can be prevented and even reversed by immunization of the mice with the Abeta peptide. Similar protection could be achieved by passive… CONTINUE READING
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www.pnas.org cgi doi 10.1073 pnas.0436286100 Bard

  • D. Schenk
  • Nat. Rev. Neurosci
  • 2002

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