Epitope Specificity of Anti-Citrullinated Protein Antibodies

  title={Epitope Specificity of Anti-Citrullinated Protein Antibodies},
  author={Nicole Hartwig Trier and Gunnar Houen},
Anti-citrullinated protein antibodies are primarily associated with a progressive course in the autoimmune disease rheumatoid arthritis, a disease with a chronic and inflammatory nature. These antibodies do not appear to have any strict dependency for reactivity except from the presence of the non-genetically encoded amino acid citrulline, which is the result of a posttranslational modification, catalyzed by calcium-dependent peptidylarginine deiminase enzymes. Nevertheless, several amino acids… CONTINUE READING