Epitope Specificity Determines Pathogenicity and Detectability of Anti-Platelet-Derived Growth Factor Receptor α Autoantibodies in Systemic Sclerosis.

@article{Moroncini2015EpitopeSD,
  title={Epitope Specificity Determines Pathogenicity and Detectability of Anti-Platelet-Derived Growth Factor Receptor α Autoantibodies in Systemic Sclerosis.},
  author={Gianluca Moroncini and Antonella Grieco and Giulia Nacci and Chiara Paolini and Cecilia Tonnini and Katarzyna Natalia Pozniak and Massimiliano Cuccioloni and Matteo Mozzicafreddo and Silvia Svegliati and Mauro Angeletti and Andrius Kazlauskas and Enrico Vittorio Avvedimento and Ada Funaro and Armando Gabrielli},
  journal={Arthritis & rheumatology},
  year={2015},
  volume={67 7},
  pages={1891-903}
}
OBJECTIVE To identify the epitopes recognized by autoantibodies targeting platelet-derived growth factor receptor α (PDGFRα) in systemic sclerosis (SSc) and develop novel assays for detection of serum anti-PDGFRα autoantibodies. METHODS Epstein-Barr virus-immortalized B cells from 1 patient with SSc (designated PAM) were screened for expression of IgG binding to PDGFRα and induction of reactive oxygen species in fibroblasts. The variable regions of anti-PDGFRα IgG were cloned into an IgG… CONTINUE READING
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