Epitope Dampening Monotypic Measles Virus Hemagglutinin Glycoprotein Results in Resistance to Cocktail of Monoclonal Antibodies

@inproceedings{Lech2013EpitopeDM,
  title={Epitope Dampening Monotypic Measles Virus Hemagglutinin Glycoprotein Results in Resistance to Cocktail of Monoclonal Antibodies},
  author={Patrycja Joanna Lech and Gregory J. Tobin and Ruth V. Bushnell and Emily Gutschenritter and Linh Duy Pham and Rebecca A. Nace and Els Verhoeyen and François-Lo{\"i}c Cosset and ClaudeP. Muller and Stephen Russell and Peter L. Nara},
  booktitle={PloS one},
  year={2013}
}
The measles virus (MV) is serologically monotypic. Life-long immunity is conferred by a single attack of measles or following vaccination with the MV vaccine. This is contrary to viruses such as influenza, which readily develop resistance to the immune system and recur. A better understanding of factors that restrain MV to one serotype may allow us to predict if MV will remain monotypic in the future and influence the design of novel MV vaccines and therapeutics. MV hemagglutinin (H… CONTINUE READING

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