Epithelin/granulin growth factors: extracellular cofactors for HIV-1 and HIV-2 Tat proteins.

@article{Trinh1999EpithelingranulinGF,
  title={Epithelin/granulin growth factors: extracellular cofactors for HIV-1 and HIV-2 Tat proteins.},
  author={Don Trinh and Kevin M Brown and K T Jeang},
  journal={Biochemical and biophysical research communications},
  year={1999},
  volume={256 2},
  pages={299-306}
}
Epithelin/granulin growth factor is synthesized as a 593 amino acid precursor protein that contains 7.5 imperfectly conserved repeats of approximately 57 amino acids. Processed epithelin/granulin peptides have been isolated from vertebrate/invertebrate species and are growth factors implicated in epithelial and haemic cell function. Here they are identified as Human Immunodeficiency Virus (HIV) Tat binding proteins using the yeast two-hybrid assay. Intracellularly in yeast, mutation of selected… CONTINUE READING

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