Epithelial-to-mesenchymal transition induced by TGF-β1 is mediated by AP1-dependent EpCAM expression in MCF-7 cells.

@article{Gao2015EpithelialtomesenchymalTI,
  title={Epithelial-to-mesenchymal transition induced by TGF-β1 is mediated by AP1-dependent EpCAM expression in MCF-7 cells.},
  author={Jiujiao Gao and Qiu Yan and Jiao Wang and Shuai Liu and Xuesong Yang},
  journal={Journal of cellular physiology},
  year={2015},
  volume={230 4},
  pages={775-82}
}
The epithelial-to-mesenchymal transition (EMT), a process involving the breakdown of cell-cell junctions and loss of epithelial polarity, is closely related to cancer metastasis and invasion. The epithelial cell adhesion molecule (EpCAM) is a type I transmembrane protein expressed in the majority of normal epithelial tissues and overexpressed in the majority of human epithelial cancers including breast cancer. EpCAM plays an important role in cancer progression. We showed that EpCAM… CONTINUE READING

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