Epithelial to mesenchymal transition in gingival overgrowth.

  title={Epithelial to mesenchymal transition in gingival overgrowth.},
  author={Siddika Selva Sume and Alpdogan Kantarci and Alan Chee Guan Lee and Hatice Hasturk and Philip C Trackman},
  journal={The American journal of pathology},
  volume={177 1},
Epithelial to mesenchymal transition (EMT) occurs normally in development. In pathology, EMT drives cancer and fibrosis. Medication with phenytoin, nifedipine, and cyclosporine-A often causes gingival overgrowth. Based partly on the histopathology of gingival overgrowth, the present study investigates the hypothesis that EMT could contribute to its development. We found that phenytoin-induced human gingival overgrowth tissues, the most fibrotic drug-induced variety, contain diminished… CONTINUE READING
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