Epithelial-to-mesenchymal transition in fibrosis: collagen type I expression is highly upregulated after EMT, but does not contribute to collagen deposition.

@article{Hosper2013EpithelialtomesenchymalTI,
  title={Epithelial-to-mesenchymal transition in fibrosis: collagen type I expression is highly upregulated after EMT, but does not contribute to collagen deposition.},
  author={Nynke A. Hosper and Paul P van den Berg and Saskia de Rond and Eliane R. Popa and Martijn J Wilmer and Rosalinde Masereeuw and Ruud A. Bank},
  journal={Experimental cell research},
  year={2013},
  volume={319 19},
  pages={
          3000-9
        }
}
The hallmark of fibrosis is an accumulation of fibrillar collagens, especially of collagen type I. There is considerable debate whether in vivo type II epithelial-to-mesenchymal transition (EMT) is involved in organ fibrosis. Lineage tracing experiments by various groups show opposing data concerning the relative contribution of epithelial cells to the pool of myofibroblasts. We hypothesized that EMT-derived cells might directly contribute to collagen deposition. To study this, EMT was induced… CONTINUE READING
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