Epithelial-to-mesenchymal transition in cyst lining epithelial cells in an orthologous PCK rat model of autosomal-recessive polycystic kidney disease.

@article{Togawa2011EpithelialtomesenchymalTI,
  title={Epithelial-to-mesenchymal transition in cyst lining epithelial cells in an orthologous PCK rat model of autosomal-recessive polycystic kidney disease.},
  author={Hiroko Togawa and Koichi Nakanishi and Hironobu Mukaiyama and Taketsugu Hama and Yuko Shima and Mayumi Sako and Masayasu Miyajima and Kandai Nozu and Kazuhiro Nishii and Shizuko Nagao and Hisahide Takahashi and Kazumoto Iijima and N. Yoshikawa},
  journal={American journal of physiology. Renal physiology},
  year={2011},
  volume={300 2},
  pages={F511-20}
}
In polycystic kidney disease (PKD), cyst lining cells show polarity abnormalities. Recent studies have demonstrated loss of cell contact in cyst cells, suggesting induction of epithelial-to-mesenchymal transition (EMT). Recently, EMT has been implicated in the pathogenesis of PKD. To explore further evidence of EMT in PKD, we examined age- and segment-specific expression of adhesion molecules and mesenchymal markers in PCK rats, an orthologous model of human autosomal-recessive PKD. Kidneys… CONTINUE READING
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