Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer.

@article{Arumugam2009EpithelialTM,
  title={Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer.},
  author={Thiruvengadam Arumugam and Vijaya Ramachandran and Keith Francis Fournier and Huamin Wang and Lauren Marquis and James L Abbruzzese and Gary E. Gallick and Craig D. Logsdon and David James McConkey and Woonyoung Choi},
  journal={Cancer research},
  year={2009},
  volume={69 14},
  pages={5820-8}
}
A better understanding of drug resistance mechanisms is required to improve outcomes in patients with pancreatic cancer. Here, we characterized patterns of sensitivity and resistance to three conventional chemotherapeutic agents with divergent mechanisms of action [gemcitabine, 5-fluorouracil (5-FU), and cisplatin] in pancreatic cancer cells. Four (L3.6pl, BxPC-3, CFPAC-1, and SU86.86) were sensitive and five (PANC-1, Hs766T, AsPC-1, MIAPaCa-2, and MPanc96) were resistant to all three agents… CONTINUE READING
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