Epithelial to mesenchymal transition and cancer stem cell phenotypes leading to liver metastasis are abrogated by the novel TGFβ1-targeting peptides P17 and P144.

@article{Zubeldia2013EpithelialTM,
  title={Epithelial to mesenchymal transition and cancer stem cell phenotypes leading to liver metastasis are abrogated by the novel TGFβ1-targeting peptides P17 and P144.},
  author={Idoia G. Zubeldia and Anne-Marie Bleau and Miriam Redrado and Diego Molina Serrano and Alice Agliano and Carmen Gil-Puig and Fernando Vidal-Vanaclocha and Jon Lecanda and A. M. Rochas Calvo},
  journal={Experimental cell research},
  year={2013},
  volume={319 3},
  pages={
          12-22
        }
}
Colorectal cancer (CRC) frequently metastasizes to the liver, a phenomenon that involves the participation of transforming-growth-factor-β(1) (TGFβ(1)). Blockade of the protumorigenic effects elicited by TGFβ(1) in advanced CRC could attenuate liver metastasis. We aimed in the present study to assess the antimetastatic effect of TGFβ(1)-blocking peptides P17 and P144, and to study mechanisms responsible for this activity in a mouse model. Colon adenocarcinoma cells expressing luciferase were… CONTINUE READING
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