Epithelial to Mesenchymal Transition by TGFβ-1 Induction Increases Stemness Characteristics in Primary Non Small Cell Lung Cancer Cell Line

@inproceedings{Pirozzi2011EpithelialTM,
  title={Epithelial to Mesenchymal Transition by TGFβ-1 Induction Increases Stemness Characteristics in Primary Non Small Cell Lung Cancer Cell Line},
  author={Giuseppe Pirozzi and Virginia Tirino and Rosa Camerlingo and Renato Franco and Aantonello La Rocca and Eleonora Liguori and Nicola Massimiliano Martucci and Francesca Paino and Nicola Normanno and Gaetano Rocco},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Cancer Stem Cells (CSCs) hypothesis asserts that only a small subset of cells within a tumour is capable of both tumour initiation and sustainment. The Epithelial-Mesenchymal Transition (EMT) is an embryonic developmental program that is often activated during cancer invasion and metastasis. The aim of this study is to shed light on the relationship between EMT and CSCs by using LC31 lung cancer primary cell line. MATERIALS AND METHODS A549 and LC31 cell lines were treated with 2… CONTINUE READING