Epithelial tight junctions, gene expression and nucleo-junctional interplay.

  title={Epithelial tight junctions, gene expression and nucleo-junctional interplay.},
  author={Karl Matter and Maria Susana Balda},
  journal={Journal of cell science},
  volume={120 Pt 9},
Tight junctions are components of the junctional complex linking neighbouring epithelial cells and are important for barrier formation. Recent evidence suggests that tight junctions also participate in signal transduction mechanisms that regulate epithelial cell proliferation, gene expression, differentiation and morphogenesis. One important class of tight-junction-associated signal transduction mechanism is based on dual localisation of certain proteins both at junctions and in the nucleus… CONTINUE READING