Epithelial-stromal interaction 1 (EPSTI1) substitutes for peritumoral fibroblasts in the tumor microenvironment.

  title={Epithelial-stromal interaction 1 (EPSTI1) substitutes for peritumoral fibroblasts in the tumor microenvironment.},
  author={Michala de Neergaard and Jiyoung Kim and Ren{\'e} Villadsen and Agla J. R. Fridriksdottir and Fritz Rank and Vera Timmermans-Wielenga and Anita Langer\od and Anne-Lise B\orresen-Dale and Ole William Petersen and Lone R\onnov-Jessen},
  journal={The American journal of pathology},
  volume={176 3},
Tumor cells can activate stroma, yet the implication of this activation in terms of reciprocal induction of gene expression in tumor cells is poorly understood. Epithelial Stromal Interaction 1 (EPSTI1) is an interferon response gene originally isolated from heterotypic recombinant cultures of human breast cancer cells and activated breast myofibroblasts. Here we describe the first immunolocalization of EPSTI1 in normal and cancerous breast tissue, and we provide evidence for a role of this… CONTINUE READING


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