Epithelial sodium channel modulates platelet collagen activation.

@article{Cerecedo2014EpithelialSC,
  title={Epithelial sodium channel modulates platelet collagen activation.},
  author={Doris Cerecedo and Ivette A Mart{\'i}nez-Vieyra and Lea Alonso-Rangel and Claudia Guadalupe Ben{\'i}tez-Cardoza and Arturo Ortega},
  journal={European journal of cell biology},
  year={2014},
  volume={93 3},
  pages={127-36}
}
Activated platelets adhere to the exposed subendothelial extracellular matrix and undergo a rapid cytoskeletal rearrangement resulting in shape change and release of their intracellular dense and alpha granule contents to avoid hemorrhage. A central step in this process is the elevation of the intracellular Ca(2+) concentration through its release from intracellular stores and on throughout its influx from the extracellular space. The Epithelial sodium channel (ENaC) is a highly selective Na… CONTINUE READING

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