Epithelial protein lost in neoplasm modulates platelet-derived growth factor-mediated adhesion and motility of mesangial cells.

@article{Tsurumi2014EpithelialPL,
  title={Epithelial protein lost in neoplasm modulates platelet-derived growth factor-mediated adhesion and motility of mesangial cells.},
  author={Haruko Tsurumi and Yutaka Harita and Hidetake Kurihara and Hidetaka Kosako and Kenji Hayashi and Atsuko Matsunaga and Yuko Kajiho and Shoichiro Kanda and Kenichiro Miura and Takashi Sekine and A. A. Kompiang Oka and Kiyonobu Ishizuka and Shigeru Horita and Motoshi Hattori and Seisuke Hattori and Takashi Igarashi},
  journal={Kidney international},
  year={2014},
  volume={86 3},
  pages={548-57}
}
Mesangial cell migration, regulated by several growth factors, is crucial after glomerulopathy and during glomerular development. Directional migration requires the establishment of a polarized cytoskeletal arrangement, a process regulated by coordinated actin dynamics and focal adhesion turnover at the peripheral ruffles in migrating cells. Here we found high expression of the actin cross-linking protein EPLIN (epithelial protein lost in neoplasm) in mesangial cells. EPLIN was localized in… CONTINUE READING
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