Epithelial permeability to proteins in the noninflamed ileum of Crohn's disease?

@article{Sderholm1999EpithelialPT,
  title={Epithelial permeability to proteins in the noninflamed ileum of Crohn's disease?},
  author={Johan Dabrosin S{\"o}derholm and Kajsa Holmgren Peterson and Gunnar P. Olaison and Lennart E. Franz{\'e}n and Bj{\"o}rn R. Westr{\"o}m and Kristina Kallin Magnusson and Rune I Sj{\"o}dahl},
  journal={Gastroenterology},
  year={1999},
  volume={117 1},
  pages={
          65-72
        }
}
BACKGROUND & AIMS Crohn's disease (CD) is associated with a disturbed intestinal barrier. Permeability studies have focused on inert molecules, but little is known about transepithelial transport of macromolecules with antigenic potential in humans. The aim of this study was to quantify permeation and to characterize passage routes for macromolecules in ileal mucosa in CD. METHODS Noninflamed and inflamed ileal mucosa specimens from patients with CD (n = 12) and ileal specimens from patients… CONTINUE READING
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