Epithelial neoplasia in Drosophila entails switch to primitive cell states.

@article{Khan2013EpithelialNI,
  title={Epithelial neoplasia in Drosophila entails switch to primitive cell states.},
  author={Sumbul Jawed Khan and Anjali Bajpai and Mohammad A Alam and Ram Prakash Gupta and Sneh Harsh and Ravi Krishan Pandey and Surbhi Goel-Bhattacharya and Aditi Nigam and Arati Mishra and Pradip Sinha},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 24},
  pages={E2163-72}
}
Only select cell types in an organ display neoplasia when targeted oncogenically. How developmental lineage hierarchies of these cells prefigure their neoplastic propensities is not yet well-understood. Here we show that neoplastic Drosophila epithelial cells reverse their developmental commitments and switch to primitive cell states. In a context of alleviated tissue surveillance, for example, loss of Lethal giant larvae (Lgl) tumor suppressor in the wing primordium induced epithelial… CONTINUE READING
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