Epithelial-mesenchymal transition is necessary for acquired resistance to cisplatin and increases the metastatic potential of nasopharyngeal carcinoma cells.

@article{Zhang2014EpithelialmesenchymalTI,
  title={Epithelial-mesenchymal transition is necessary for acquired resistance to cisplatin and increases the metastatic potential of nasopharyngeal carcinoma cells.},
  author={Pei Zhang and Hao Liu and Fei Xia and Qian Zhang and Yuan Zhang and Qing Rui Zhao and Zhen Hua Chao and Zhi Wen Jiang and Chen Chen Jiang},
  journal={International journal of molecular medicine},
  year={2014},
  volume={33 1},
  pages={
          151-9
        }
}
Radiotherapy and adjuvant cisplatin (DDP) chemotherapy are standard approaches used in the treatment of nasopharyngeal carcinoma (NPC). However, resistance to chemotherapy has recently become more common, resulting in the failure of this combination therapy for NPC. The aim of the present study was to assess the cellular morphology, motility and molecular changes in DDP-resistant NPC cells in relation to epithelial-mesenchymal transition (EMT). CNE2 cells were continuously exposed to increasing… CONTINUE READING

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High expression of Zinc-finger protein X-linked is associated with reduced E-cadherin expression and unfavorable prognosis in nasopharyngeal carcinoma.

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  • 2015
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