Epithelial-mesenchymal transition induced by the stromal cell-derived factor-1/CXCR4 system in oral squamous cell carcinoma cells.

@article{Onoue2006EpithelialmesenchymalTI,
  title={Epithelial-mesenchymal transition induced by the stromal cell-derived factor-1/CXCR4 system in oral squamous cell carcinoma cells.},
  author={Tomitaro Onoue and Daisuke Uchida and Nasima Begum and Yoshifumi Tomizuka and Hideo Yoshida and Mitsunobu Sato},
  journal={International journal of oncology},
  year={2006},
  volume={29 5},
  pages={
          1133-8
        }
}
Epithelial-mesenchymal transition (EMT) refers to critical events occasionally observed during tumor progression, including invasion and metastasis, by which cancer cells acquire a fibroblast-like phenotype. Since the stromal cell-derived factor-1 (SDF-1)/CXCR4 system can facilitate lymph node metastasis in oral squamous cell carcinoma (SCC), we have explored the possibility that this system might be involved in EMT. Oral SCC cells, B88 and HNt, which have functional CXCR4 and lymph node… CONTINUE READING

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  • 2018
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