Epithelial-mesenchymal transition induced by transforming growth factor-{beta}1/Snail activation aggravates invasive growth of cholangiocarcinoma.

  title={Epithelial-mesenchymal transition induced by transforming growth factor-\{beta\}1/Snail activation aggravates invasive growth of cholangiocarcinoma.},
  author={Yasunori Sato and Kenichi Harada and Keita Itatsu and Hiroko Kurimasa Ikeda and Yuko Kakuda and Syuji Shimomura and Xiang Shan Ren and Norihide Yoneda and Motoko Sasaki and Yasuni Nakanuma},
  journal={The American journal of pathology},
  volume={177 1},
Epithelial-mesenchymal transition is an important mechanism behind initiation of cancer invasion and metastasis. This study was performed to clarify the involvement of epithelial-mesenchymal transition in the progression of cholangiocarcinoma. Cholangiocarcinoma cell lines, CCKS-1 and TFK-1, were treated with transforming growth factor-beta1 (TGF-beta1), and the phenotypic changes and invasive activity were examined. Immunohistochemical analysis was performed using tissue sections of… CONTINUE READING


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