Epithelial-mesenchymal transition in ovarian cancer progression: a crucial role for the endothelin axis.

@article{Bagnato2007EpithelialmesenchymalTI,
  title={Epithelial-mesenchymal transition in ovarian cancer progression: a crucial role for the endothelin axis.},
  author={Anna Bagnato and Laura Rosan{\`o}},
  journal={Cells, tissues, organs},
  year={2007},
  volume={185 1-3},
  pages={85-94}
}
In ovarian carcinoma, acquisition of invasiveness is accompanied by the loss of the epithelial features and the gain of a mesenchymal phenotype, a process known as epithelial-mesenchymal transition (EMT). The endothelin A receptor (ET(A)R)/endothelin-1 (ET-1) axis is overexpressed in primary and metastatic ovarian carcinoma. In this tumor type, the ET-1/ET(A)R axis has a critical role in ovarian carcinoma progression by inducing proliferation, survival, neoangiogenesis, loss of intercellular… CONTINUE READING
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