Epithelial mesenchymal transition in human ocular chronic graft-versus-host disease.

  title={Epithelial mesenchymal transition in human ocular chronic graft-versus-host disease.},
  author={Yoko Ogawa and Shigeto Shimmura and Tetsuya Kawakita and Satoru Yoshida and Yutaka Kawakami and Kazuo Tsubota},
  journal={The American journal of pathology},
  volume={175 6},
Chronic graft-versus-host disease (cGVHD) of the ocular surface and lacrimal gland is a vision-threatening condition that occurs after allogeneic bone marrow transplantation. In this study, we used immunohistochemistry and electron microscopy to investigate whether epithelial mesenchymal transition (EMT) contributed to the pathogenesis of ocular cGVHD. We detected down-regulation of E-cadherin and translocation of beta-catenin from the intercellular junction to the cytoplasm and nucleus of… CONTINUE READING


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