Epithelial-mesenchymal transition in carcinomas of the female genital tract.

@article{Stewart2013EpithelialmesenchymalTI,
  title={Epithelial-mesenchymal transition in carcinomas of the female genital tract.},
  author={Colin J R Stewart and W Glenn McCluggage},
  journal={Histopathology},
  year={2013},
  volume={62 1},
  pages={31-43}
}
Invasion is a defining feature of malignancy, but the mechanisms of invasion in many common cancers, including gynaecological malignancies, remain unclear. However, it has been proposed that malignant cells may usurp a normal embryological process, epithelial-mesenchymal transition (EMT), as a means of acquiring migratory capacity. The synergistic role of the tumour microenvironment in EMT induction has also been explored and helps to explain the spatially restricted distribution of EMT at the… CONTINUE READING
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