Epithelial-mesenchymal transition enhances nanoscale actin filament dynamics of ovarian cancer cells.

@article{Lee2013EpithelialmesenchymalTE,
  title={Epithelial-mesenchymal transition enhances nanoscale actin filament dynamics of ovarian cancer cells.},
  author={Sunyoung Lee and Yang Yang and David A. Fishman and Mark M Banaszak Holl and Seungpyo Hong},
  journal={The journal of physical chemistry. B},
  year={2013},
  volume={117 31},
  pages={9233-9240}
}
Epithelial ovarian cancer cells enhance their ability to migrate and invade through the epithelial-mesenchymal transition (EMT), resulting in cell seeding and metastasis in the peritoneal cavity and onto adjacent organ surfaces. It has been speculated that cytoskeletal dynamics, such as those of the actin filament, play a role in enhanced cell motility; however, direct evidence has not been provided. Herein, we have directly measured pico- to nanonewton-scale mechanical forces generated by… CONTINUE READING