Epithelial-mesenchymal transition and cancer stem cells, mediated by a long non-coding RNA, HOTAIR, are involved in cell malignant transformation induced by cigarette smoke extract.

@article{Liu2015EpithelialmesenchymalTA,
  title={Epithelial-mesenchymal transition and cancer stem cells, mediated by a long non-coding RNA, HOTAIR, are involved in cell malignant transformation induced by cigarette smoke extract.},
  author={Yi Liu and Fei Luo and Yuan Xu and Bairu Wang and Yongxi Zhao and Wenchao Xu and Le Shi and Xiaolin Lu and Qizhan Liu},
  journal={Toxicology and applied pharmacology},
  year={2015},
  volume={282 1},
  pages={9-19}
}
The incidence of lung diseases, including cancer, caused by cigarette smoke is increasing, but the molecular mechanisms of gene regulation induced by cigarette smoke remain unclear. This report describes a long noncoding RNA (lncRNA) that is induced by cigarette smoke extract (CSE) and experiments utilizing lncRNAs to integrate inflammation with the epithelial-mesenchymal transition (EMT) in human bronchial epithelial (HBE) cells. The present study shows that, induced by CSE, IL-6, a pro… CONTINUE READING